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CK 666

CAS No. 442633-00-3

CK 666( CK 0944666 )

Catalog No. M14508 CAS No. 442633-00-3

CK 666 (CK 0944666) is a small molecule Arp2/3 complex inhibitor with IC50 of 4 uM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    CK 666
  • Note
    Research use only, not for human use.
  • Brief Description
    CK 666 (CK 0944666) is a small molecule Arp2/3 complex inhibitor with IC50 of 4 uM.
  • Description
    CK 666 (CK 0944666) is a small molecule Arp2/3 complex inhibitor with IC50 of 4 uM, inhibits actin polymerization with either BtArp2/3 complex (IC50=17 uM) or SpArp2/3 complex (IC50=5 uM); reduces actin polymerization around intracellular Listeria to background levels (Fig. 2e and g) at lower concentrations than CK-636; alters the morphology and slightly slowed but did not stop the gliding motility of fish keratocytes.
  • In Vitro
    CK-666 (100 μM) significantly reduces the number of filopodia on the cell surface of treated trabecular meshwork (TM) cells as well as reduces the length of those filopodia that are present.
  • In Vivo
    ——
  • Synonyms
    CK 0944666
  • Pathway
    Cytoskeleton/Cell Adhesion Molecules
  • Target
    Arp2/3 complex
  • Recptor
    Arp2/3 complex
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    442633-00-3
  • Formula Weight
    296.345
  • Molecular Formula
    C18H17FN2O
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO : 125 mg/mL 421.81 mM
  • SMILES
    CC1=C(C2=CC=CC=C2N1)CCNC(=O)C3=CC=CC=C3F
  • Chemical Name
    2-fluoro-N-[2-(2-methyl-1H-indol-3-yl)ethyl]benzamide

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Hetrick B, et al. Chem Biol. 2013 May 23;20(5):701-12. 2. Nolen BJ, et al. Nature. 2009 Aug 20;460(7258):1031-4. 3. Yi K, et al. Nat Cell Biol. 2011 Aug 28;13(10):1252-8.
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    A small molecule Arp2/3 complex inhibitor that inhibits actin polymerization stimulated by fission yeast Arp2/3 complex.

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  • CK 666

    CK 666 (CK 0944666) is a small molecule Arp2/3 complex inhibitor with IC50 of 4 uM.

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